What Are Sinus Issues? Living with sinus issues is like forever living with the flu. The discomfort may be mild or more severe, but it always seems to be there like a bad cold you can't shake. It may not seem like the worst health problem you can have, but the constant discomfort makes it difficult to get through the day without a struggle. In the long term, sinus issues can lead to breathing difficulties or put you at risk for infections.